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Tirzepatide clears the body in approximately 5 days per half-life (about 25 days total clearance), while semaglutide takes approximately 7 days per half-life (about 35 days total clearance)

This is the same receptor system that slows gastric emptying to create satiety

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Among prescription options, orlistat typically has fewer systemic side effects because it doesnt affect hormones or appetite signaling

Stopping is reasonable only if you've achieved your weight goal, sustained behavioral changes for months, and have a clear plan to prevent regain through diet and exercise