as hCG levels peak and placental progesterone secretion rises, hCG secretion would be reduced
Together, these actions: Increase insulin release only when blood glucose is elevated Reduce excess glucose production by the liver Slow stomach emptying, limiting post-meal glucose spikes Act on appetite centres in the brain, increasing fullness and reducing hunger Because insulin release is glucose-dependent, Mounjaro on its own has a low risk of causing hypoglycaemia (low blood sugar), unless combined with insulin or sulfonylurea medications
Safety and Efficacy of GLP-1RAs in Weight Management
Tirzepatide specifically is interesting because it is the most effective weight loss drug ever tested in clinical trials, and because its dual mechanism offers additional receptor targets
Multiple analyses show that when treatment is stopped, most people regain some or all of the weight they lostsometimes moreand that the cardiometabolic benefits do not persist off-drug
Bowen J, Noakes M, Clifton PM