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The approval positions the pill as a potential alternative to injectable GLP-1 therapies and is expected to become available in the US in early January 2026

Note: Servier Medical Art illustrations were used under CC BY 4.0 for mechanism figures ( Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes PMC )

10.2174/1567205015666180911151716 118 PeraltaM.LizcanoF

The publication fee of this article will be funded by Universidad UTE

The American Thyroid Association does not routinely recommend combination therapy but acknowledges it may benefit select patients with persistent symptoms despite normal TSH on levothyroxine alone

[33] Studies suggest that tirzepatide can lower the risk of cardiovascular disease and improve cardiovascular outcomes: GIP and GLP-1 are natural incretin hormones that play a role in liver function