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For specific scenarios, check our guides on how long compounded semaglutide can be unrefrigerated , how long compounded tirzepatide can be out of the fridge , and whether GLP-1 must be refrigerated
Moreover, it appears that it is the membrane-bound form of the enzyme, on sites such as the luminal surface of capillary endothelial cells, which is more important for GLP-1 degradation than the circulating (soluble) enzyme (74, 75), questioning the relevance of any association between the plasma activity per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity
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Patients should be counseled to eat smaller portions, avoid high-fat meals, and stay adequately hydrated
