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There is no fixed, validated timeline because the product is unregulated and individual responses differ

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Hulst AH, Plummer MP, Hollmann MW, DeVries JH, Preckel B, Deane AM et al (2018) Systematic review of incretin therapy during peri-operative and intensive care

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The available therapeutic strategies for IR are mainly exercise and dietary habit improvement, and chemotherapy based on biguanides and glucagon-like peptide-1, and traditional Chinese medicine treatments (e.g., herbs and acupuncture) can also be helpful