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With GLP-1 medications, this may happen due to delayed gastric emptying, which allows food to remain in the stomach longer, potentially leading to bacterial fermentation and gas production with a characteristic sulphurous odour

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As body fat decreases, total aromatase activity decreases, which can shift the androgen-to-estrogen ratio

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When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases