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Regulation of glutamate release by 7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals

The enrichment analysis of the significantly more abundant KOs in T2, T3 and T4 indicated that carbon ( metF , kdgK and abfD ), pyrimidine ( pydC and ushA ) and cysteine/methionine ( AHCY , mtnA ) were enriched in T2, arginine, alanine, aspartate and glutamate metabolism ( argB , argG , glnA ) and the pentose phosphate pathway ( TALDO1 and PRPS ) were enriched in T3 and thermogenesis/oxidative phosphorylation ( CYTB , ATPeF0A , ND1 , ND2 and ND6 ), the two-component system/ lysine degradation/ aminobenzoate degradation/ butanoate metabolism ( atoD , atoA , CYTB , tctA and kdd ) and the metabolism of glycine, serine and threonine ( kbl and thrH ) and the degradation of flavonoids ( phy ) were enriched in T5

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A deeper understanding of the molecular mechanisms involved in MTX-induced intestinal injury may help to explain a number of the drugs toxicities and develop multiple strategies to be investigated to ameliorate the harmful adverse effects of MTX

The difference is that GHK-Cu activates it biochemically, systemically, and without requiring physical tissue injury