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It is commonly referenced in preclinical and laboratory research examining neuropeptide signalling, circadian rhythm regulation, and central nervous systemrelated biochemical pathways within controlled research systems
GLP-1 drugs, which mimic one or more gut hormones, act on the body in ways both known and yet to be discovered
High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression
Currently available GLP-1 receptor agonists in the UK include: Exenatide (short-acting and extended-release formulations) - licensed for type 2 diabetes Liraglutide (once-daily injection) - licensed for type 2 diabetes (Victoza) and separately for weight management (Saxenda 3mg) Dulaglutide (once-weekly injection) - licensed for type 2 diabetes, including cardiovascular risk reduction in those with established cardiovascular disease or multiple risk factors Semaglutide (once-weekly injection and oral formulation) - licensed for type 2 diabetes (Ozempic, Rybelsus) and separately for weight management (Wegovy 2.4mg) A related but distinct medication is tirzepatide (once-weekly injection), which is a dual GIP/GLP-1 receptor agonist licensed for type 2 diabetes management
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