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According to FDA prescribing information, fatigue occurs in approximately 11% of patients taking Wegovy and 5-9% of patients taking Saxenda

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Looking from 2023 to 2024, the latest year of data available, prescriptions and gross spending for Wegovy (first approved for obesity in 2021, approved for cardiovascular disease in 2024) and Mounjaro (approved for type 2 diabetes in 2022) more than doubled, and prescriptions and gross spending for Zepbound (first approved for obesity in 2023, approved for sleep apnea in 2024) increased more than fivefold

Additional pathways exist to access GLP-1 medications through systematic approaches that address coverage gaps and alternative procurement methods

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2e and Supplementary Table 1)