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A number of studies have looked at the benefits of L-Carnitine supplementation, and they generally agree that the 1,000 mg to 2,000 mg range is effective for fat loss

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For example, a Cleveland Clinic study from June 2025, involving 7,881 participants, found that high-dose tirzepatide users lost 18.0% of their body weight in one year, semaglutide users lost 13.7%, and those who discontinued early (within three months) lost just 3.6%

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RAND also found that another 14% of Americans were interested in trying a GLP-1 drug