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The STEP (Semaglutide Treatment Effect in People with obesity) 1 trial was a randomized, placebo-controlled trial that evaluated the efficacy of once-weekly subcutaneous (SC) semaglutide 2.4 mg plus lifestyle interventions in adults with obesity without diabetes (n = 1961)
Patents cover coformulations with SGLT2 inhibitors, thyroid hormone receptor beta agonists, and other metabolic targets [25, 26], mirroring the scientific literature's growing focus on GLP-1's effects across MASH, cardiovascular disease, and other obesity-related conditions [27, 28]
This helps lower blood sugar levels in people with diabetes
In contrast, those who only implemented lifestyle changes saw an average decrease of 2.4% in their weight
X.Dcarie-SpainL.GuC.MazziniG.KanoskiS
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