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Oxidative stress contributes to metastasis by influencing multiple steps of the metastatic cascade, including epithelial-mesenchymal transition (EMT), invasion, intravasation, survival in the circulation, extravasation, and colonization of distant organs [118]

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With ongoing advancements in nanomaterial design and bio-responsive mechanisms, multifunctional nanoplatforms hold promise for integrated bladder cancer diagnosis and treatment in clinical applications, offering patients safer and more efficient therapeutic approaches ( Figure 6 )