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doi: 10.3389/FMICB.2018.02928 137 PinoP.PellegrinoG.RonchettiS.MolleaC.BoscoF.OnidaB

To prevent polymerisation of each added amino acid, its alpha amino group and reactive side chains are masked with a temporary protecting group

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The risk of cholelithiasis among different GLP1-RAs Table 4 showed the overall relative risk of cholelithiasis was 1.2, 1.3, and 1.4 in liraglutide, dulaglutide, and semaglutide versus control with number needed to harm of 17.25, 14.69, and 10.96, respectively

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215,216 The GIP/GLP-1 receptor agonists have an additional agonism effect at the GIP receptor, resulting in increased insulin secretion in a glucose dependent manner and combined effects on appetite regulation and weight loss