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This is the most significant limitation No statistical significance testing: The paper does not report p-values or statistical tests

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doi: 10.1038/s41380-025-02911-7 51 Melo Dos SantosLSTrombetta-LimaMEggenBDemariaM

Using sterile water beyond a single use or sharing it between patients can risk contamination, since it has no agent to suppress bacterial growth

Standard research dose: 525mg/day oral Timing: Morning, pre-cardio or fasted Cycling: 812 weeks on / 4 weeks off is a reasonable protocol based on general NNMT inhibitor principles Form: Most sources provide capsules or powder