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Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)
After that, it can be several more years before you develop pernicious anemia symptoms
This complete absence of immunogenic response indicates that the peptide structure is sufficiently similar to endogenous sequences that the immune system does not recognize it as foreign