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Allergic reactions, although rare, could also occur

If your medication accidentally freezes, whether in a refrigerator set too cold, during shipping, or during travel , the freeze-thaw cycle damages the peptide structure

Kindel TL, Wang AY, Wadhwa A et al (2025) Multi-society clinical practice guidance for the safe use of glucagon-like peptide-1 receptor agonists in the perioperative period

Patients with pre-existing liver disease or gallbladder dysfunction require closer monitoring

Critical rule: never place the medication directly against a frozen gel pack

That extra GIP activity is why tirzepatide tends to produce greater average weight loss in head-to-head trials, though both are FDA-approved and share a similar side-effect profile