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Additionally, the review highlights morin hydrate as a promising adjuvant that enhances cisplatin efficacy in hepatocellular carcinoma while reducing its systemic toxicity

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Conclusion and future perspectives Glutamine metabolism plays a central role in the regulation of uncontrolled tumor growth by supplying metabolic intermediates as a carbon and nitrogen source and by maintaining the redox homeostasis against oxidative stress during rapid proliferation

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However, it may also be an indication of other factors or conditions, such as oxidative stress

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Theoretically, availability of GSH as an intact molecule declines when consumed orally, which could explain why oral glutathione was less effective

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