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Agitation: Excessive shaking of the vial can physically damage the protein structure

Diabetic complications : Diabetes is associated with glycation of proteins, including enzymes like GR, potentially impairing their function

Accumulating evidence has revealed that changes in microglial functions (for example, morphological changes, process movement, and inflammation) are required for the development of chronic pain [60,61,62]

Mendes MM et al

Your GP may refer you to gynaecology or endocrinology services if menstrual disturbances persist despite appropriate management, or if there are features suggesting underlying hormonal disorders beyond the effects of weight change

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