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However, bacterial biofilm in chronic wounds may cause irreversible bacterial adhesion, leading to persistent inflammation, tissue damage, and ongoing infection [43, 45, 46]

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Sci Rep 6:33072 Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgzolu L, Nordestgaard BG, Bruckert E, de Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, Mrz W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN, European Atherosclerosis Society Consensus Panel, Stroes E, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgzolu L, Nordestgaard BG, Bruckert E, Krauss RM, Laufs U, Santos RD, Mrz W, Newman CB, John Chapman M, Ginsberg HN, John Chapman M, Ginsberg HN, de Backer G, Catapano AL, Hegele RA, Kees Hovingh G, Jacobson TA, Leiter L, Mach F, Wiklund O (2015) Statin-associated muscle symptoms: impact on statin therapyEuropean Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management

If after a trial the nausea is debilitating and doesnt lessen, that patient might not continue therapy