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It is produced to support controlled experimental workflows where consistency, handling convenience, and reproducibility are essential

When the chi square test and I 2 statistic results had a considerable issue, then the need for further discussion and conclusion for the heterogeneity was indicated

Regarding MAPK1 and MAPK3, studies have reported that they are involved in BRCA through several approaches, including the activation of cell cycle-related proteins and inhibition of antiapoptotic proteins by MAPK1/MAPK3 phosphorylation, and regulation of cytoskeletal proteins to promote migration 36

Supplemental Material Abbreviations cAMP cyclic AMP IR insulin receptor PKB protein kinase B PDE3B phosphodiesterase 3B AR adrenergic receptor HSL hormone-sensitive lipase AC adenylyl cyclase ODE ordinary differential equation

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