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A possible explanation for the sex difference in metformins protective effect could lie in the hormonal context: higher baseline adiponectin levels in women may already confer protection, whereas in men, metformin partly compensates for their lower adiponectin levels and higher baseline risk
Roberts, J.C
10.3892/etm.2020.9089 150
They were developed on the basis of either human GLP-1 or exendin-4, a 39-amino acid peptide isolated from the Gila monster ( Heloderma suspectum ) venom, which shares 53% homology with GLP-1 [38]
PMID: 14671407 LeRoith D, Yakar S
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