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Accepted: Dec 27, 2021 DOI: 10.4093/dmj.2021.0280
It works by mimicking an incretin hormone that enhances insulin release, suppresses glucagon secretion, and slows gastric emptying, which in turn lowers blood sugar levels, as well as promotes weight loss
Like any medication, GLP-1 receptor agonists can come with common side effects, including nausea, vomiting, diarrhea, and fatigue
For the glucagon receptor, the binding affinity differs substantially between species, with mouse Ki values approximately 13-fold higher than human values, indicating weaker binding in the mouse model [6] [7] [8]
People with severe gastrointestinal conditions: Such as gastroparesis, since the medication slows gastric emptying and may exacerbate these conditions
But dosing decisions are medical
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