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Cardiovascular outcome trials have demonstrated significant reductions in major adverse cardiovascular events with certain agents in this class (liraglutide, injectable semaglutide, and dulaglutide), leading to expanded indications for cardiovascular risk reduction

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Naunyn-Schmiedeberg s Archives of Pharmacology, 393(5), 761-775

Nausea, mild vomiting, and gastrointestinal changes are most common with semaglutide initiation, typically resolving within 2-4 weeks

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