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A big difference between semaglutide and tirzepatide is that semaglutide mimics the action of one hormone GLP-1 while tirzepatide mimics the action of two, a GLP-1 and something called a GIP, or glucose-dependent insulinotropic polypeptide

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Participants taking liraglutide also achieved a 5.5% total body weight change compared with placebo over the 48-week study period

CagriSema versus tirzepatide in people with type 2 diabetes