Not a marginal trend
6 Thinking back to the science behind GLP-1s, this makes sense
The Problem: Why Most Glutathione Supplements Dont Work Heres where things get frustrating
The direct receptor effect is considered a secondary contributor, with weight loss being the dominant factor, but it adds an incremental layer of risk that's specific to GLP-1 medications
N Engl J Med 384(12):11131124 Osaka T, Endo M, Yamakawa M, Inoue S (2005) Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system
The study, which is based on analysis of adverse reactions within the World Health Organizations global database, found reports of suicidal thoughts were slightly higher than expected for semaglutide, even when compared to other diabetes drugs