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Insoluble dietary fiber (Non-starch polysaccharides) from rice bran attenuates cadmium-induced toxicity in mice by modulating the gut microbiota and alleviating liver and kidney injury

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The mean (SD) absolute weight loss from the index date to the end of follow-up was 14.6 (9.9) kg in the semaglutide 2.4 mg cohort and 17.2 (11.7) kg in the tirzepatide cohort, which represented a mean (SD) percent weight loss of 14.1% (9.6) and 16.5% (10.8), respectively

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Finally, one can foresee a future where combination therapy becomes common: for example, a patient with diabetes and obesity might be on both a GLP-1 RA and an SGLT2 inhibitor (for complementary weight loss and cardio-renal protection, which is already done)

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For example, the Krispy Kreme stock was downgraded by several investment banks from buy to hold, with the stock price dropping c.14% in the immediate wake of the SELECT trial announcement in August 2023 (from $14.40 to $12.43) due to the uncertain impact that the rise in weight-loss drugs will have on the future sales of the business

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doi: Bader S, Bhatti R, Mussa B, Abusanana S

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