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A recent randomized study just published in the Lancet in 2025 evaluated 194 folks randomly assigned to Exenatide (n=97) or placebo (n=97)

Its important to note that GLP-2, a hormone involved in intestinal growth, is not targeted by either of these medications

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People With Diabetes: The Need for Screening and Early Intervention

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The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks