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Each of these compounds is a peptide-based agonist , but they differ in their receptor targeting and metabolic impact which translates to meaningful differences in fat loss outcomes, metabolic markers, and lean body mass preservation
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Key examples: Diabetes + CKD = diabetic CKD (E11.22) no explicit caused by diabetes statement needed Diabetes + neuropathy = diabetic neuropathy (E11.4x) Diabetes + retinopathy = diabetic retinopathy (E11.3xx) Diabetes + periodontal disease = diabetic periodontal disease (E11.630) However, the provider must not document that the condition is NOT related to diabetes
What has become increasingly clear since 2023 is that GLP-1 receptors are also active in areas of the brain involved in reward, impulse control, motivation, and stress regulation
2020;5(17):e140532
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