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PCR data showed that 200 M H 2 O 2 treatment upregulated IL-1, MMP13, Collagen-X, Caspase3, and Caspase9 at mRNA level in chondrocytes, while metformin significantly attenuated these H 2 O 2 exposure induced increases (Fig

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Additionally, a large pipeline of entero-pancreatic hormone-based pharmacotherapies is under development, with the aim to enhance and/or compliment the efficacy and mechanisms of action of GLP-1 RA (Table 1, Fig

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