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International Journal of Environmental Research and Public Health, 18(11), 5533

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression

Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining

Cascella R, Evangelisti E, Zampagni M, Becatti M, DAdamio G, Goti A, Liguri G, Fiorillo C, Cecchi C

It activates both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor