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For parallel and tau-equivalent items, the Spearman-Brown formula accurately estimates reliability based on reductions to scale length

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5 Dose escalation, gastrointestinal class effects, and economic constraints When the elimination half-life is short and steady-state accumulation is negligible, the most intuitive response in oral peptide and protein development has been dose escalation

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Chronic inflammation negatively affects the blood-brain barrier and leads to a pro-inflammatory phenotype of astrocytes and microglia (Rochfort and Cummins, 2015)