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La OMS inst a una accin rpida y coordinada para ampliar el acceso a las terapias GLP-1 , mejorar la asequibilidad y fortalecer los sistemas de salud

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Both are generally well-tolerated, though GI side effects from semaglutide (nausea, diarrhea) may overlap with metformin-induced gastrointestinal symptoms early in treatment

98 Although located in the sinoatrial node, GLP-1 RAs influence the cardiovascular system through several other mechanisms, including the use of myocardial glucose, improvement of left ventricular function, myocardial ischaemic protection, increased heart rate, vasodilation, anti-atherosclerotic effects, and blood pressure reduction

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Enhanced Protein Synthesis and Nitrogen Retention IGF-1 DES directly upregulates amino acid uptake and incorporation into muscle protein, independent of insulin or growth hormone