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Interestingly, a role for UCP2 in the transport of mGSH has been described in neurons, suggesting that the transport of protons back into the matrix by UCP2 may favor the movement of GSH ( MITOCHONDRIAL MEMBRANE PROPERTIES AND IMPACT ON GLUTATHIONE IMPORT Previous studies in liver mitochondria have revealed that membrane dynamics regulate the transport of mGSH

Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk

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Effect of long-term vagal stimulation on food intake and body weight during diet induced obesity in rats

Int Immunopharmacol 71:233240

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