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Remarkably, the fruit fly Drosophila melanogaster , expresses a GSTE14 with notable steroid isomerase activity, even though Ser14 has evolved as the active-site residue corresponding to Tyr9 in the mammalian alpha class

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Fifty years later, no receptor for it has been identified

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The peptide shares approximately 48% amino acid sequence homology with insulin and binds to insulin receptors, though with lower affinity than insulin itself