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References Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic The objective of this study was to evaluate the efficacy, onset of action, duration of action, and side effects of 1% diphenhydramine compared with 1% lidocaine when used as a local anesthetic agent

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Intra-articular corticosteroid injections, topical or oral analgesics, and other local procedures remain clinically relevant, particularly for short-term pain relief and for patients with acute symptom exacerbation (Bensa et al., 2024)