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The substitution of Met66 results in a higher affinity of prodomain to Zn 2+ , owing to the His40-mediated stabilization of its multimeric structure
Its short half-life is a real constraint on any incubation in a protease-containing medium
many of these drugs are also approved in other countries, but may have different indications and costs
BER loaded nanoformulations directed for intranasal administration have been previously reported in several studies
The clinical evidence exists but is limited small trials, older studies, no large RCTs
Oral glutathione supplements rarely has any side effects
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