36 Current evidence suggests a possible link to depressive or suicidal ideation specific to semaglutide 37, and a clearly higher incidence of gastrointestinal adverse events compared with liraglutide.38 Both remain FDA-approved and well-studied
Versatile UsageCan be mixed with water, milk, cereals, porridge, or used in baking for a protein boost in various recipes
Whilst some supplements (such as certain probiotics or omega-3 fatty acids) show promise in research settings, evidence remains preliminary
Primary endpoint of ACHIEVE Secondary endpoint of ACHIEVE for weight loss There were many other new GLP-1 family of drugs and combinations presented without publications in NEJM or The Lancet or are in development
Its primary approved indication in the United States is the reduction of excess abdominal fat in HIV-positive adults with lipodystrophy, a condition characterised by abnormal fat redistribution often associated with antiretroviral therapy
Clinical trials (SUSTAIN-6) have shown cardiovascular benefits with semaglutide, though this is not a specific licensed indication in the UK
