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The most common side effects of oral silymarin ingestion include:2 Abdominal pain/fullness Bloating Bowel changes Diarrhea Dyspepsia (indigestion) Flatulence Headache Nausea Pruritus (itching) Of note, there's at least one case report of more severe instances of the above, along with sweating, colicky pain, weakness, and collapse, in a 57-year-old woman after taking a milk thistle capsule

Published 2020 Feb 27

Hepatoma Res

On the other hand, excessive intake of certain nutrients, such as iron and copper, can increase oxidative stress and disrupt metal homeostasis, leading to tissue damage and impaired detoxification

nucleatum -positive CRC