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Given the extensive physiological functions and drug development potential of GLP-1R, targeting GLP-1R has become one of the important approaches in treating obesity
The bioactive that matters is EGCG (epigallocatechin-3-gallate), the primary catechin responsible for most of the documented metabolic effects
Other brand names for semaglutide are Wegovy and Rybelsus
Glucagon, the third target unique to Retatrutide among weight loss medications, primarily drives energy expenditure but may also modulate reward circuitry in ways we are only beginning to understand
Phase 3 will also involve the SURPASS 2 study, which will be a comparison with semaglutide (Ozempic), and it is expected to finish before 2022
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