These reports describe reduced limb circumference, decreased heaviness, and improved mobility
Additionally, the pain will often be associated with other symptoms, such as: Paresthesia: an abnormal sensation, whether spontaneous or evoked, typically not painful, according to the International Association for the Study of Pain
PMid:21833551
Apixaban's FDA label explicitly warns against co-administration with strong dual CYP3A4/P-gp inhibitors such as ketoconazole, itraconazole, and ritonavir, and strong dual inducers like rifampin and carbamazepine (FDA Eliquis Prescribing Information)
Thats pretty different from a weekly injectable
If a patient has mild to moderate renal (kidney) or hepatic (liver) insufficiency, special care is required