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Thus, it is unclear whether effects differed between hip, vertebral, wrist, or other fractures. Mir Ali, MD, a bariatric surgeon, bariatric medicine specialist and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, likewise not involved in this study, also noted that this research shows a benefit of semaglutide over other diabetes treatment approaches. However, Ali cautioned, it is difficult to attribute the improvement solely to semaglutide based on this study alone

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However, selective knockdown of GLP-1R in the DVC only partially perturbs normal energy balance, whereas GLP-1R knockdown in the hypothalamus does not result in any energy balance impairment 60

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