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Among the included studies, four studies included T2D patients [27, 32, 37, 40], another four studies included T2D at higher CVD [36, 38, 39, 41], seven studies included patients with T2D combined with CVD [28,29,30,31, 33, 34], and the remaining two studies included patients with T2D had established CVD, CKD, or both [15, 19]

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This synergistic fat metabolism effect is the primary reason tirzepatide outperforms semaglutide in every head-to-head trial conducted to date

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