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We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation

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Toxicol in Vitro 25(8):17121720 Rudin CM, Yang Z, Schumaker LM, Vanderweele DJ, Newkirk K, Egorin MJ, Zuhowski EG, Cullen KJ (2003) Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance

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