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Finally, given the pragmatic nature of the proposed trial, the decision was taken to include consecutive patients seeking medical help at the participating centres, thus ensuring the enrolment of subjects similar to those that would be seen in normal clinical practice

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The most consistent finding: researchers who dose MOTS-c in the morning during fasted states report more pronounced shifts in substrate utilizationmeasured via respiratory exchange ratio (RER)than those administering it post-meal

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