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Get urgent medical care right away if you have severe symptoms like intense or persistent abdominal pain, signs of an allergic reaction (such as swelling, hives, or trouble breathing), or symptoms of significant dehydration

I confess that I had never heard of NAION until I read the recent JAMA article about its possible association with GLP-1 RA medications

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The dermis contains the highest concentration of these sensory nerve endings, which explains why the initial skin puncture typically causes the most noticeable sensation