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SURPASS-2 pitted tirzepatide (5mg, 10mg, and 15mg/weekly) against semaglutide (1mg/weekly) and directly compared their effectiveness for T2D management in almost 2000 study volunteers for 40 weeks [22]

STEP-1 showed 39% of semaglutide weight loss was lean mass

Increased Fatigue or Brain Fog Others feel more tired, especially during the first few weeks of treatment