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Consistent with these results, mouse embryonic fibroblasts (MEFs) lacking the clock activator Bmal1 displayed reduced CI respiration, whereas MEFs lacking the repressors Cry1 and Cry2 exhibited increased CI respiration (Fig

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To date, only few studies have examined the effects of LC supplementation for at least 12 weeks, which is, on the other hand, the main limitation of the current review

Most studies have been conducted in animal models or small human trials with high risk of bias, and findings often lack replication in larger, well-controlled clinical studies

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