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NF-kappaB ist ein zentraler Transkriptionsfaktor, der die Expression hunderter entzuendungsfoerdernder Gene steuert

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Individuals with the CT genotype had lower hypertension risk, systolic blood pressure, blood glucose, and plasma MDA levels than those with the CC genotype, suggesting that the PPARD rs7770619 SNP could be a potential candidate gene for hypertension [248]

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The glutamic-acid substitution sterically prevents binding to IGF-binding proteins (IGFBPs), leaving a far larger fraction of the peptide free to engage the IGF-1 receptor (IGF-1R)