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Probiotics enhance intestinal barrier function by increasing the expression of tight junction proteins (claudin-1, ZO-1, and occludin), improving transepithelial resistance, and increasing mucus production (MUC2, MUC3, and MUC1) 113
Unlike pharmacological interventions that target single receptors or pathways, GHK-Cus multi-gene modulation touches many of the hallmarks of aging simultaneously: Genomic instability (DNA repair gene upregulation) Epigenetic alterations (chromatin remodeling via altered transcription factor activity) Loss of proteostasis (chaperone and proteasome pathway modulation) Cellular senescence (anti-apoptotic and anti-senescence gene networks) Altered intercellular communication (anti-inflammatory cytokine modulation) This positions GHK-Cu within what researchers increasingly call multi-hallmark peptide therapy a conceptual framework that prioritizes compounds acting across multiple aging mechanisms simultaneously
The peptide extends the anagen (growth) phase of hair follicles while shortening the telogen (resting) phase
May 2022;14(5):e25543
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