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On the other hand, direct modulation of metabolism and mediation of FGF21s cytoprotective effects in liver, described below, likely requires agonism of FGFR2c and possibly FGFR3c

(4) Activation of glycine salvage pathways is achieved through enhanced glycine cleavage system components, which is capable of facilitating serine/pyruvate interconversion to maintain redox balance

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